Quino-what?”

We hear that a lot.

Before we explain what it is and why we are committed to helping victims, let’s start with how it is pronounced.

Quinolone: kwĭn’ə-lōn’

Fluoroquinolone: flu̇r-ō-ˈkwi-nə-ˌlōn\

History and difference between quinolones and fluoroquinolones.

The words ‘quinolone’ and ‘fluoroquinolone’ are often interchanged but there is a difference between the two. Both are terms for a class of antibiotics based on Nalidixic acid.

Nalidixic acid is the first of the synthetic quinolone antibiotics. It was discovered in 1962 by George Lesher and used clinically in 1967. Originally, in smaller doses Nalidixic acid inhibited growth and replication of bacteria; in higher doses it killed bacteria.

The addition of a fluorine atom is what differentiates quinolones from fluoroquinolones. Fluorine is an element; F2 on the Periodic Table. It is a toxic gas and is considered one of the most reactive elements. The addition of the fluorine atom and a piperazine ring make quinolones more powerful, more able to penetrate the blood-brain barrier, increases biological stay time, and the altering of molecular recognition.

Bottom line: the addition of fluorine and a piperazine ring enhances the effects of quinolones- and amplifies its toxic effects.

Fluoroquinolones became second (1987), third (1996) and fourth (1997) generation quinolones. Second generation fluoroquinolones include Cipro (ciprofloxacin) and Floxin (ofloxacin); third generation fluoroquinolones include Levaquin (levofloxacin) and Avelox (moxifloxacin); fourth generation fluoroquinolone include Factive (gemifloxacin).

Quinolones and fluoroquinolones can cause severe adverse reactions and fluoroquinolone-associated disability (FQAD) and the risks often outweigh the benefits. Please do your research and ask for a safer alternative.

Adverse Reactions to Quinolones

Community members have reported the following adverse reactions to fluoroquinolones. This should not be considered an exhaustive list of possible reactions, nor is it meant to be a diagnostic tool for fluoroquinolone toxicity. Consult your physician if you think you are suffering from an adverse reaction to a fluoroquinolone.

  • Tendinitis
  • Tendon rupture
  • Ligament rupture
  • Meniscus tear in knee
  • Joint pain/popping
  • Muscle atrophy/weakness/pain
  • Degeneration of spinal disks
  • Peripheral neuropathy/nerve pain/nerve damage
  • Fatigue
  • Dental pain
  • Facial pain/numbness
  • Muscle twitching/involuntary spasms
  • Tremors
  • Insomnia
  • Brain fog
  • Anxiety/depression
  • Impaired memory
  • Speech/aphasia
  • Suicidal ideation
  • Seizures
  • Visual/auditory hallucinations
  • Non-allergy itching
  • Poor wound healing
  • Swallowing deficit
  • Persistent gastric problems
  • Mouth sores
  • Food/chemical sensitivities
  • Dry/itchy eyes
  • Lack of tear production
  • Visual changes
  • Retina tears
  • Vertigo
  • Tinnitus
  • Palpitations/arrhythmia
  • High/low blood pressure
  • Dysautonomia

Currently Prescribed Quinolones

We make every effort to keep this list up to date, but you should always carefully check every new antibiotic prescription you receive to ensure it is not a fluoroquinolone.

Oral Fluoroquinolones

  • Avelox (moxifloxacin)
  • Cipro (ciprofloxacin)
  • Factive (gemifloxacin)
  • Levaquin (levafloxacin)
  • Noroxin (norfloxacin)

Fluoroquinolone Eye Drops

  • Besivance (besifloxacin)
  • Cetraxal, Ciloxan (ciprofloxacin)
  • Iquix, Quixin (levofloxacin)
  • Ocuflox (ofloxacin)
  • Vigamox (moxifloxacin)
  • Zymar (gatifloxacin)
  • Moxeza (moxifloxacin)

Fluoroquinolone Ear Drops

  • Cetraxal, Ciprodex (ciprofloxacin)
  • Floxin (ofloxacin)
  • Xtoro (finafloxacin)

Inhaled Fluoroquinolones

  • Quinsair (levofloxacin)

Fluoroquinolones Pending FDA Approval

  • Baxdela (delafloxacin)

Veterinary Fluoroquinolones

— Yes, they flox our pets too!
  • Advocin, Advocid (danofloxacin)
  • Dicural, Vetequinon (difloxacin)
  • Floxasol, Saraflox, Sarafin (sarafloxacin)
  • Ibaflin (ibafloxacin)
  • Marbocy, Zeniquin (marbofloxacin)
  • Orbax, Victas (orbifloxacin)

Comprehensive List of Past and Present Quinolones

QVF_website_list_of_fluoroquinolones