Fluoroquinolone Toxicity (FQT), also known as fluoroquinolone-associated disability (FQAD), is a serious, debilitating, potentially deadly condition that continues to devastate people worldwide. The Quinolone Vigilance Foundation is dedicated to discovering underlying mechanisms involved in fluoroquinolone toxicity, finding a cure, and to improving care for fluoroquinolone patients. Our donors are critical towards finding treatments and a cure.

Before a research project becomes a reality there are numerous hours of behind the scenes conferences, negotiations, and collaborations. Research will then translate any discoveries into effective medical practices, therapies, and public health approaches.

The Quinolone Vigilance Foundation is a registered 501(c)(3) non-profit organization. Your contribution is tax deductible to the full extent allowed by law and you will receive a receipt for your donation of any amount.

Current Research

Research: Retrospective data collection of Fluoroquinolone adverse events

Location: Undisclosed ±

Dates: Began October 13, 2016

Objective: To collect and study accurate data from participating major hospitals, medical records, and healthcare databases to determine how many patients required follow-up care for adverse events after taking a fluoroquinolone versus a non-fluoroquinolone antibiotic.

Status: Active

Research: Single-nucleotide polymorphisms (SNPs)

Location: Undisclosed ±

Dates: Began 2014

Objective: To determine the role of genetic markers and single-nucleotide polymorphisms (SNPs) and whether there is a genetic predisposition component to fluoroquinolone toxicity.

Status: Active

Research: Analysis of Fluoroquinolone toxicity in the central nervous system (CNS)

Location: University of Rochester

Objective: To establish whether fluoroquinolones cause neurological toxicity, to identify potential target cells and dosages that are of concern and to identify possible drug interactions that enhance toxicity. In addition, this work has the goal of identifying molecular mechanisms potentially responsible for such toxicity, including the identification of physiological states that might make some individuals more vulnerable to the toxic effects of these compounds.

Status: Active

Completed Research

Research: Azithromycin and Levofloxacin Use and Increased Risk of Cardiac Arrhythmia and Death

Location: University of South Carolina

Began Spring 2011
Received for publication May 16, 2013
Revision received August 30, 2013
Accepted for publication September 12, 2013

Objective: To establish whether Azithromycin and Levofloxacin use increases risk of cardiac arrhythmia and death

Status: Completed and published

Research: Mitochondrial Dysfunction in Gulf War Illness

Location: University of California- San Diego

Objective: To objectively assess for mitochondrial dysfunction, examining post-exercise phosphocreatine-recovery time constant (PCr-R) using 31Phosphorus Magnetic Resonance Spectroscopy (31P-MRS), in Gulf War veterans with Gulf War illness compared to matched healthy controls.

Dates: Published March 27, 2014

Status: Completed and published

Proposed Research

  • Mitochondrial damage associated with Fluoroquinolone Toxicity
  • Analysis of Neuropsychiatric responses associated with Fluoroquinolone Toxicity

± Note: One of the goals of QVF is to fund research related to fluoroquinolone toxicity. To accomplish this, we must ensure that any research conducted remains unbiased. Disclosing the names and locations of people and facilities potentially makes them vulnerable to outside influences and jeopardizes our cause. Some research studies have been made public. However, some researchers have asked us to keep information confidential to prevent outside influences and keep the project unbiased. By not disclosing where some research takes place we are protecting your donation and our cause. We take every precaution to ensure that any research project is not funded by the pharmaceutical industry. We rely on private donations to fund our projects and greatly appreciate everyone who helps us fund vital research.